Estradiol 50-28-2 - Estradiol 50-28-2

Product Name: Estradiol 50-28-2
Synonyms :1,3,5-estratriene-3,17beta-diol,17beta-estradiol,3,17beta-dihydroxy-1,3,5(10)-estratriene,dihydrofolliculin
Molecular Formula: C18H24O2
CAS Registry Number : 50-28-2
EINECS : 200-023-8
Assay: 98% min.
Appearance: White or yellowish crystalline powder, scentless.
Usage: pharmaceutical material, Steroid hormone, estrogen, hypoestrogenism.
Estrogen is marketed in a number of ways to address issues of hypoestrogenism. Thus, there are oral, transdermal, topical, injectable, and vaginal preparations. Furthermore, the estradiol molecule may be linked to an alkyl group at C3 position to facilitate the administration. Such modifications give rise to estradiol acetate (oral and vaginal applications) and to estradiol cypionate (injectable).
Oral preparations are not necessarily predictably absorbed, and are subject to a first pass through the liver, where they can be metabolized, and also initiate unwanted side effects. Therefore, alternative routes of administration that bypass the liver before primary target organs are hit have been developed. Transdermal and transvaginal routes are not subject to the initial liver passage.
Ethinylestradiol, the most common estrogen ingredient in combined oral contraceptive pills, is a more profound alteration of the estradiol structure.