Rifampicin - 13292-46-1

Rifampicin (INN) ( /rɪˈfæmpəsɪn/) or rifampin (USAN) is a bactericidal antibiotic drug of the rifamycin group. It is a semisynthetic compound derived from Amycolatopsis rifamycinica (formerly known as Amycolatopsis mediterranei and Streptomyces mediterranei).Rifampicin may be abbreviated R, RMP, RA, RF, or RIF (US).
In 1957, a soil sample from a pine forest on the French Riviera was brought for analysis to the Lepetit Pharmaceuticals research lab in Milan, Italy. There, a research group headed by Prof. Piero Sensi (1920-) and Dr. Maria Teresa Timbal (1925 – 1969) discovered a new bacterium. This new species appeared immediately of great scientific interest since it was producing a new class of molecules with antibiotic activity. Because Sensi, Timbal and the researchers were particularly fond of the French crime story Rififi (about a jewel heist and rival gangs), they decided to call these compounds “rifamycins”. After two years of attempts to obtain more stable semi-synthetic products, a new molecule with high efficacy and good tolerability was produced in 1959 and was named “rifampicin”.
Rifampicin is also known as rifaldazine, R/AMP, rofact (in Canada), and rifampin in the United States. There are various types of rifamycins from which this is derived, but the rifampicin form, with a 4-methyl-1-piperazinaminyl group, is by far the most clinically effective.
Rifampicin is an intensely red solid, and the small fraction which reaches body fluids is known for imparting a harmless red-orange color to the urine (and to a lesser extent, also sweat and tears) of users, for a few hours after a dose. Maximal concentrations in the blood are decreased by about a third when the antibiotic is taken with food.
Rifampicin is used in the treatment of a number of bacteria, but best known for activity against Mycobacterium strains, such as cause tuberculosis and Hansen’s Disease. Rifampicin can be used as monotherapy for a few days as prophylaxis against meningitis, but resistance develops quickly during long treatment of active infections, so the drug is always used against active infections in combination with other antibiotics.

Product name: Rifampicin (Rifampin)
CAS No. 13292-46-1
Chemical name: 3-{[(4-Methyl-1-piperazinyl)imino]-methyl}rifamycin
Molecular formula: C43H58N4O12
Molecular weight: 822.95
Applications: Antibiotics for the treatment of tuberculosis.
Appearance: A Reddish Brown to Brownish Red Crystalline powder.
Specification: BP/USP/EP.
Bulk Density: 0.3g/ml; 0.5g/ml; 0.7g/ml; 0.8g/ml
Standard Packaging: 5kgs/drum; 25kgs/drum; 25kgs/carton
Indications

Rifampicin was introduced in 1967, as a major addition to the cocktail-drug treatment of tuberculosis and inactive meningitis, along with isoniazid, ethambutol, pyrazinamide and streptomycin. It requires a prescription in North America. It must be administered regularly daily for several months without break; otherwise, the risk of drug-resistant tuberculosis is greatly increased. In fact, this is the primary reason that it is used in tandem with the three aforementioned drugs, particularly isoniazid. This is also the primary motivation behind directly observed therapy for tuberculosis.
Rifampicin resistance develops quickly during treatment and rifampicin monotherapy should not be used to treat these infections — it should be used in combination with other antibiotics.
Rifampicin is also used in the treatment of cholestatic pruritus.

Mycobacteria
Rifampicin is typically used to treat Mycobacterium infections, including tuberculosis and Hansen’s Disease. It can be used to treat BCG-oma, which follows as an uncommon complication of BCG vaccination for tuberculosis.
With multidrug therapy used as the standard treatment of Hansen’s Disease, rifampicin is always used in combination with dapsone and clofazimine to avoid eliciting drug resistance.

Other bacteria
Rifampicin also has a role in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in combination with fusidic acid, although recent inquiries have raised questions over the lack of studies into the efficacy of this treatment. It is used in prophylactic therapy against Neisseria meningitidis (meningococcal) infection.
It is also used to treat infection by Listeria species, Neisseria gonorrhoeae, Haemophilus influenzae and Legionella pneumophila. For these non-standard indications, sensitivity testing should be done (if possible) before starting rifampicin therapy.
The Enterobacteriaceae, Acinetobacter, and Pseudomonas species are intrinsically resistant to rifampicin.
Further, it has been used with amphotericin B in largely unsuccessful attempts to treat primary amoebic meningoencephalitis caused by Naegleria fowleri.

Virus
Rifampicin has some effectiveness against vaccinia virus.