Cholic acid CAS81-25-4

mp  200-201 °C(lit.)

alpha  36 º (c=0.6, 95% EtOH)

storage temp.  Store at RT. solubility  methanol: 0.1 g/mL, clear

Water Solubility  0.28 g/L (15 ºC)

Merck  14,2203

BRN  2822009

CAS DataBase Reference 81-25-4(CAS DataBase Reference)

NIST Chemistry Reference Cholic acid(81-25-4)

EPA Substance Registry System Cholan-24-oic acid, 3,7,12-trihydroxy-, (3.alpha.,5.beta.,7.alpha., 12.alpha.)-(81-25-4)

chemical property

This product is present in bovine, sheep, pig bile. Colorless flaky or white crystalline powder. Some bitter, taste some sweet feeling.

Mp198 DEG C, specific rotation (c=0.6, ethanol) + 37 degrees, besides the above acid about dissolved in a 300 ml ethanol or acetone, 7ml of glacial acetic acid and very little soluble in water. Water complexes for white sheet crystal.1927, H.Wieland (Germany) on bile acid composition, won the Nobel Prize in chemistry.

Efficacy

A with steroid structure of organic acid, emulsified fat, promote digestion. Artificial bezoar raw material medicine, used in health care products and food additives and feed additive.

Introduction

Cholic  acids are produced in the liver from cholesterol. 

The major functions of cholic acids

 are to assist in the solubilization ,emulsification and utilization of fats and 

fatsoluble vitamins, protect the health of liver &gallbladder.

Adding bile acids has  three major benefits

Functions

1 Improve fat utilization, solve the problem of low digestion 

  and provide enough energy, promote growth, 

  save protein and feed cost.

2 Aquatic animal couldn’t absorb fat completely which 

   will easily induce fatty liver syndrome , feed bile acids can 

    protect liver and gallbladder, prevent fatty liver syndrome

    and keep fish health.

3 Improve the ability of anti-stress and help to decrease 

   the death rate during transportation

4 For shrimp and other crustaceans , they could not secret bile 

acids and cholesterol themselves, adding bile acid can increase cholesterol 

utilization in order to convert into molting hormone and promote 

  transformation and growth.

Dosage

species Adding dosage(g/t)

Grass-carp 200-250

crucian 200-300

tilapia 150-200

weever 600-1000

eels 400-800

prawns 600-800

Crustaceans  300-600 Packing:  25KG/Drum.

Shelf life:  24 months

Storage:  Stored in shaded dry, cool place with good ventilation.

Application of cholic acids in animal husbandry

A. Effects of cholic acids on the performance of piglets

In order to ensure enough energy in piglets fed diet, need to add in the feed formulation in fat, however, Zi liver function is not perfect, and undigested fat easily cause diarrhea, in the feed to add bile acids can solve the problem of piglets in fat digestion. The Ohio State University Reinhart, (1989) in weanling pig diets adding 0.3% bile acid significantly increased body weight gain and feed intake, fat intake and fat table absorption amount increased, nitrogen intake and nitrogen storage allowance also significantly increased (P < 0.01).

B. effects of cholic acids on the production performance of poultry

Bile acid can effectively improve the performance of poultry.Gomez (1979), reported that feed add bile acid, the white Plymouth Rock chicken fat apparent digestibility increased 2.l%. bile acid can improve broiler on fat utilization (Pullen, l983).

Fatty liver of laying hens are laying hens common a nutritional and metabolic diseases, affect liver function and serious caused by rupture of liver cells, liver hemorrhage and death. Suffering from fatty liver of chickens is difficult to appear laying peak, to the aquaculture industry brings great economic losses, in feed to add extra bile acid can prevent fatty liver caused a series of problems, conducive to healthy hens, prolong the duration of egg laying peak.

C. effects of cholic acids on the growth of aquatic animals

Feed add bile acid can improve the nutritional value of snapper feeds. The weight gain rate of 45.73% ~ 68.6% higher than the control group, improve feed utilization 10.86% ~ 21.88% (disciple pill repair, 1981). Systems such as (2003) in the feed to add 100 mg / kg of Likang (bile acids), Allogynogenetic silver crucian carp growth rate increased by 5.1%, feed conversion rate was increased by 22.9%, reduce the proportion of visceral, fish feed ratio has been increased. Ishihara Xiura (1987), also found that feed add bile acid, improve Pagrosomus major color, improve the commodity value of the fish farming.

D. the effect of cholic acids on the appearance and quality of animal fur

Bile acids can increase the absorption of fat and fat soluble vitamins in animals, thereby improving the quality of animal fur.

In short, bile acid as a feed additive, can effectively alleviate the fat and fat soluble vitamins due to indigestion caused by a variety of problems, improve the conversion rate of fat, reduce the cost of feed.